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longchamp outlet How to Do a forward roll

November
20

How to Do a forward roll

Versatile players with power moves under the basket as well as outside shots. Learn how to play forward and low post in this free basketball lesson video from an experienced coach.

Part 1 of 15 How to Play forward in youth basketball.

The Oklahoma Roll is a great wrestling move that can be used when an opponent has been beating up pretty badly, and he in pain struggling to get up. It very opportunistic but also simple and is used to pin your opponent into submission. You do this by coming off the ropes and doing a forward roll over your opponent. You want your head to stay close to their body so that your head is coming across to the other side of his stomach while you rolling over. While doing this you need to take your right arm and put it over his left shoulder grabbing his left arm. Your left arm is going to.

This is a video tutorial in the Sports category where you are going to learn how to play offense in a game of soccer. The forward soccer position usually stays on the offensive side in order to score goals. Adrian Heath, head coach, shows you how to play the forward position properly. This is going to be a very easy and simple drill. All you are looking for is a nice little floating pass over the defender head to your own player in the forward position. And the forward player then tries to score the goal past the goalkeeper.

In this video, we learn how to adjust your head seat. You want to make sure the top of your stem is adjusted correctly and the spacers are adjusted correctly. Go in and tighten the top cap pole until it just snug. Then, when you grab your bike and roll it forward, go in and tighten it some more. If it too tight, it going to bind up and you won be able to turn your handle bars. Loosen them up as much as you can without them being too loose. From here, you will be able to ride your bike and enjoy!.

Sometimes you will have to pitch underhand whether you are playing softball, baseball or with little kids sometimes a lighter throw is necessary. It may seem odd and unnatural to pitch this way at first, but check out this tutorial for tips on how to toss that ball over the plate with the same force as upperhand pitching.

You Will Need:

A softball

A glove

A softball field

A catcher

A batter (optional)

Step 1: Begin from the set

Hold the ball in the glove at your waist, body relaxed, facing home plate 46 feet away. Touch the rubber slab on the pitcher’s mound with your dominant.

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Posted by LoHudBlogs.com Admin on Friday, November 20th, 2015 at 10:13 pm
Category: North Salem
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cheap moncler uk How to Check and change the engine air filter in a car

November
20

How to Check and change the engine air filter in a car

Kim the in house mechanic for Driverside shows you how to quickly and easily replace your cars air filter. The reason you would need to change your air filter is that over time the flow is reduced which consequently reduces your car’s gas mileage. To change your air filter you first need to locate it on your car. The air filter is under the hood and usually in a box that either has clips of fillip’s head screws holding the cover on. Remove these to gain access to your filter. From there you can look to see if you filter is dirty and replace it if necessary. When you’ve finished simply reattach the cover with the screws or clips and you’re good to go.

In this video tutorial, viewers learn how to check and replace the cabin air filter of a car. Most cabin air filters are located behind the glove box of the car. Now go into the car and remove the glove box and put it aside. Some cars may need the glove box to be unscrewed. Now reach in and remove the air filter. If the air filter is dirty, replace it with a new one. Once finished, simply put back in all the parts. This video will benefit those viewers who have a vehicle and would like to learn how to change the air filter to allow clean ventilation through the car.

In this tutorial, we learn how to change the engine and oil filter on a Mercedes car. First, find the oil drain plug underneath the car. Remove this, then let it drain into a pan until it finished leaking out. From here, you will place the drain plug back on, then fill up the vehicle with the correct type of oil from the hood of the car. Then, find where the oil filter is and remove it from the car. Place in the new filter, then tighten all bolts you removed. Check the level in the car to make sure there enough oil, then you are finished!.

In this video, Ed Kriston from AAA Midatlantic explains how to winterize your car. He first talks about the fuel systems. The fuel pump and fuel filter are inside the tank, and lines and hoses run from the tank to the engine. He points out the fuel lines and injectors in the engine, and recommends that you make sure there are no leaks in the lines and hoses. He demonstrates how to remove and examine the air filter and shows one that is dirty that should be replaced. A dirty air filter will compromise engine performance. This video is helpful for anyone interested in learning about.

In this video we learn how to change your engine oil and filter. First, make sure you can go underneath your vehicle. If not place it up on jacks so you can go underneath. After this, find the oil can and then remove the drain plug from it. Let the oil drain into an oil pan until it no longer drains from the car. Next, replace the plug on the bottom of the oil tank and then pop the hood on your vehicle. Remove the cap for the oil tank and then pour your new oil into it. After this, you will replace the cap on the oil tank and then turn the engine one. Check your oil to make sure it filled up.

Watch this video to learn how to do an oil change yourself just using a jack, two jack stands, wrenches, a oil filter wrench, some old rags, oil pan, oil filter, and oil. Just find the oil filter, jack up the car, situate the jack stands, and you ready to start. Once underneath, locate the drain plug, unscrew the bolt, and let it drain. After it drains screw the bolt back on, and find your oil filter. Grab the old filter and twist it off, clean the surrounding area, then replace with the new filter, hand tightening. After getting out from under the car, open the engine compartment, and.

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Posted by LoHudBlogs.com Admin on Friday, November 20th, 2015 at 10:12 pm
Category: Metropolitan Museum of Art book sale
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cheap moncler What to order at the most popular eateries in Hong Kong

November
19

What to order at the most popular eateries in Hong Kong

They operate round the clock, serving distinctly indigenous comfort food with no nonsense service and an atmosphere of bustling industriousness.Cha chaan teng culture came of age in the 1950s when Hong Kong’s increasingly cosmopolitan and westernized middle classes began to broaden their palates.The result is a melange of tastes that fuses the cuisines of the various transient populations of Hong Kong into a new pastiche cuisine:accidental fusion food. Written on paper and taped to the walls, they extend wall to wall like a madman’s scrawl.In addition to the language barrier that exists for non Cantonese speakers, this is all enough to make neophytes shy away.Here’s a short guide that highlights several surefire cha chaan teng dishes.Tai Fat’s golden milk tea is the perfect pick me up.Delicious to a teaCha chaan teng literally means "tea restaurant" the drink has an important role at these establishments.A light, weak tea is served to all customers as soon as they sit down. Some choose to use this to clean their utensils, but really it’s for drinking.The good stuff is the Hong Kong style milk tea. This iconic drink made from a mixture of strong black teas with a lot of creamy milk should be an ocher colored, velvet smooth, mellow yet fragrant concoction.A milk tea done right will distinguish a cha chaan teng from the crowd and garner legions of loyal customers.Try one, hot or cold, sweetened or sugar free, at Tai Fat Restaurant. Since then, cha chaan tengs have served up instant noodles in endless variations.Our favorite way of eating instant noodles at a cha chaan teng is to order them with stir fried meat. Hong Kong’s finest representative of this is the scallion and chicken cutlet version at Lan Fong Yuen, a landmark cha chaan teng located in the shadow of the Mid Levels escalator.The noodles, sticky and chewy, are drizzled with soy sauce and topped with chicken with a strong ginger and scallion sauce.Yes, these are the same instant noodles that you’ve likely made at home, but so much better.Stir fried instant noodles with scallion oil and sliced chicken cutlet HK$42 includes coffee or tea at Lan Fong Yuen 2 Gage St., Central; +852 2544 3895"Oil and sand" toast at Cheung Kee or what we like to call "The Iraq."Propose a toastFrench toast is neither French nor toast per se, so the fact that the Hong Kong version forges new culinary ground is not necessarily blasphemous.Hong Kong style French toast is, however, a potential coronary on a plate. A common version amounts to what is essentially a syrup slathered, deep fried peanut butter sandwich.Si Yik, a small, no frills eatery adjoining Stanley Market, seems far from the tourist hordes that proliferate nearby. More of a dai pai dong (outdoor food stall) than a cha chaan teng per se, it happens to serve the best version of Hong Kong style French toast in all of Hong Kong.

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Posted by LoHudBlogs.com Admin on Thursday, November 19th, 2015 at 10:39 pm
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cheap moncler uk 5 things you need to know Wednesday

November
19

5 things you need to know Wednesday

Republican presidential candidates Ben Carson, left, and Donald Trump appear during the CNN Republican presidential debate on Sept. 16.(Photo: Mark J. The question stands if Carly Fiorina can regain her polling numbers, and if Jeb Bush has the staying power to continue in the race.

2. House to vote on budget deal

The House is expected to vote Wednesday on a bipartisan, two year budget deal supported by the White House. The deal, which was reached this week,would suspend the debt ceiling until March 2017; that pushesany argumentover the debt limit beyond the 2016 election cycle and placesit into the hands of a new presidential administration and a new Congress. The deal also creates a two year budget plan that would bring some relief from across the board spending cuts and would createa path to avoida government shutdown in December.

House Speaker John Boehner listens as President Obama speaks to reporters at the White House in this Jan. 13, 2015, photo. (Photo: Carolyn Kaster, AP)

3. Former House speakerto plead guilty

Former House speaker Dennis Hastert who is accused of lying to the FBI about making structured bank transactions to pay hush money to someone he wronged years ago is expected to plead guilty to the charges Wednesday. Hastert served 20 years in Congress and was indicted in May. While the plea agreement could mean that Hastert could spend time in prison, it could also mean that the 73 year old can keep embarrassing details about his past out of the public eye.

Former House speaker Dennis Hastert departs the federal courthouse in June in Chicago after his arraignment on federal charges that he broke federal banking laws and lied about money when questioned by the FBI. (Photo: Christian K. Lee, AP)

4. All ears tuned to the Fed for interest rate clues

Economists say there is virtually no chance the Federal Reserve will announce an interest rate hike when its two day meeting concludes Wednesday. But just what will itsay? The policymaking committeeheld off on a rate increase last month, citing global economic troubles. However,13 of 17 committeemembers still projected the central bank would raise its benchmark rate this year. Since then, job growth and some measures of consumer spending have slumped. The big drama now seems to be whether the Fed will indicate that a rate hike is still possible this year, or whether it will wait until 2016 to act.

Federal Reserve Board Chairwoman Janet Yellen answers questions at a news conference following a Federal Open Market Committee meeting Sept. 17. (Photo: Win McNamee, Getty Images)

5. Prince Harry visits the USA to help wounded warriors

Britain’s Prince Harry will join Michelle Obama and Jill Biden in Virginia on Wednesday to promote the May 2016 Invictus Games an international sporting competition for injured military members. In an effort to highlight the importance of mental health and well being inservice personnel, Harrywill visit the Fort Belvoirmilitary base to meet wounded servicemen and women. The prince spearheaded the Games last year, which were first held in London in September 2014. The 2016games will be in Orlando.

Happy birthday, Prince Harry. The ginger prince turns 31 on Sept. 15. We take a look back at his eventful 31 years. Mary’s Hospital in London with newborn Prince Henry Charles Albert David, known from that point on as just Prince Harry, on Sept. 15, 1984.

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Posted by LoHudBlogs.com Admin on Thursday, November 19th, 2015 at 10:38 pm
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cheap ray bans Red Chicken Curry Recipe

November
19

Red Chicken Curry Recipe

In a small bowl, combine the Garam Masala, turmeric, chili powder, and paprika. Mix well. Season the chicken with salt and the above spice blend. Set aside. In a large saute pan, over medium heat. Add the oil. When the oil is hot, add the chicken and brown for about 3 to 4 minutes on each side. Remove and set aside. Add the onions to the pan. Season with salt and pepper. Saute for 4 minutes or until soft. Add the garlic, tomatoes and ginger. Continue to saute for 1 minute. Add the chicken stock and reserved chicken pieces. Bring the liquid to a boil. Cover, reduce the heat to medium low and simmer for about 25 to 30 minutes or until the chicken is tender. Toast until dark, about 12 minutes, shaking the pan, often. Remove and cool. Grind the spices in a spice mill or coffee grinder into a powder. Remove and stir in the nutmeg.

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Posted by LoHudBlogs.com Admin on Thursday, November 19th, 2015 at 10:38 pm
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cheap ray bans uk Another Look at our Kashmir Policy

November
18

Another Look at our Kashmir Policy

A key corner stone of Pakistan’s foreign policy has been that it strives to improve its diplomatic position and capacity to enforce United Nations resolutions that would enable the inhabitants of the State of Jammu and Kashmir to exercise the right of self determination. Inherent in this policy is the assumption that given a choice, the people of Jammu and Kashmir would want to, either

join with Pakistan, or establish themselves as a separate country which would be friendly towards Pakistan.

Much water has flown under the bridge and the ground realities have changed quite significantly since our Kashmir policy was first formulated. It may be time to test the underlying assumptions of this policy.

a) A survey conducted in August 2007 and sponsored by media groups, Indian Express The Dawn CNN IBN showed that: " 87% of the people in the Kashmir valley wanted independence. However, joining Pakistan figures nowhere as a first preference for Kashmiris and India is onlyb) Another survey conducted in May 2010 in Indian and Pakistani administered Kashmir, taken on both sides of the Line of Control (LoC) by Robert Braddock an associate fellow at the Chatham House think tank in London, showed that: " opinions on an independent state of J were sharply divided by geographical distribution.

In the predominantly Muslim Kashmir Valley in Indian administered Kashmir, the proportion in favor of independence ranged from 74% 95%. However, in the predominantly Hindu Jammu part of Indian administered Kashmir, there was virtually no support for independence at all. This survey also indicated that If the movement across the LoC were to be fully liberalized, support for keeping the LoC rises dramatically to 85% overall.

In the Kashmir valley it rises to over 80% and in Pakistani administered Kashmir to over 90%".

c) An earlier survey reported by Dawn in April 2005 and conducted by a marketing research firm, Synovate India, showed that:

Given the low desire of the people of Occupied Kashmir wishing to join Pakistan and the uncertainty of the political disposition of an independent Kashmir vis a vis Pakistan and even Azad Kashmiris, one needs to ask the following question. Can it taken as a given that the relations between Pakistan and an independent Kashmir, were it to be created, would be as close as those between Pakistan and Azad Kashmir today? It seems that there is a high probability that while Pakistan and the Azad Kashmiris will lose control over Azad Kashmir, they maygain very little in return, in such a transaction.

If this realization gains ground within the Pakistan establishment, the Pakistani public and the Azad Kashmir population, it would drastically reduce the support the Jihadi groups receive in Pakistan.

This in turn will lead to a reduction of hostilities and activities across the border, which could go a long way in ending the repression in Occupied Kashmir and help the Kashmiri people live a more peaceful life. A new environment built on these principles will improve the chances of free cross border movement across the line of control which seems to be the desire of the Kashmiris on both sides of the border.

Please note that this change in policy can be implemented by Pakistan unilaterally since it is the interest of Pakistan and the people of Azad Kashmir. It does not require formal agreement with India. Needless to say this change will take time in view of the long history of acrimony between the two countries. It would require that serious measures are taken to stop the activities of the Jihadi groups , which have now taken on a life of their own. However, over time, such a change in policy will reduce the tensions on the eastern border.

Shrodinger Cat is the allegory for Kashmiris. Reference to enforcing the UN resolutions is farcical in historical sense considering:

1) when India approached the UN for Kashmir issue, it was under non binding Chapter Vi

2) whatever moral force any UN non binding resolution may have had, was totally eroded by the Simla agreement signed by Mrs Gandhi and Mr Bhutto, whereby Kashmir was made a bi lateral issue Pakistan pulled the rug fromunder the Kashmiris feet by signing Simla agreement.

Just like the cat, no one bothered to ask the Kashmiris at the time and now hope by both sides today is that the cat is dead the issue is whether to burn it or bury it!

Did anyone ask the Kashmiris whether they wanted to be in the proverbial box?! Today, the cat has more rights with the Animal Welfare groups ready to take Shrodinger to task for animal cruelty sides ASSUME the Kashmiris consent that they are content and happy being in the box, as many comments in coming days may exhibit. Sheer heights of hypocricy on India and Pakistan part when they try and take te moral and legal high ground on the Kashmir issue.

Raj ji with respect you confirm what I have said above about assumptions.

The article, sorry, blog, makes references to many pseudo or quasi surveys with questionable size and randomness of the samples.

The most intensive, extensive and exhaustive study was done in 2010 by Mr. Bradnock for Chatham House of London. The study was inspired and supported by Dr. Saif al Islam al Qadhafi, son of Muammar Gaddafi, and PhD from London School of Economics. The study is entitled Paths to Peace and is freely available online to general public.

The study found the following about Indian Administered Jammu Kashmir (J 2% favour joining Pakistan.

42 % favour Indepemdence.

47% favour the Indian (unofficial) position: 28% favour Joining India, and 19% favour making LOC an International Border.

Musharraf Formula means disaster. Borders can not become irrelevant. The only viable solution lies in making LoC international border allowing ease of travel to Kashmiris from both sides. If Punjab and Bengal can be divided, why not J ? and we are living with this division for past 60 years.

Independence of J K is out of question, forget India or Pakistan, even China will not accept creation of a land locked country that will attract superpowers like vultures are attracted to a dead animal. India Pakistan do not enjoy the trust required for joint management. So the only solution can be found around making LoC international border.

All the talk of right of self determination of Kashmiris is the biggest intellectual mischief. Roughly 1/3rd of population of both, India and Pakistan, live below poverty line does anyone really cares ? why so much noise on this cosmetic and fashionable term when hardly anyone who will vote understands the definition of a state ?

interest of Pakistan and Pakistani Kashmiris respect Hashim Sb, this is personification of selfishness it beggars belief that solutions are being proposed by intelligent commentators based on interests of one side or the other but not of the actual people most affected.

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Posted by LoHudBlogs.com Admin on Wednesday, November 18th, 2015 at 11:06 pm
Category: North Salem
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moncler outlet uk Ralph Lauren admits bribery at Argentina subsidiary

November
18

Ralph Lauren admits bribery at Argentina subsidiary

Between 2004 and 2009, Ralph Lauren’s Argentinian subsidiary bribed customs officials "to improperly obtain paperwork necessary for goods to clear customs; permit clearance of items without the necessary paperwork and/or the clearance of prohibited items; and on occasion, to avoid inspection entirely," the Justice Department said. Fake invoices were created to mask the payoffs, which totaled roughly $580,000, according to case documents.

The SEC and Justice Department both praised the company’s response to the misconduct.

"The [non prosecution agreement] in this matter makes clear that we will confer substantial and tangible benefits on companies that respond appropriately to violations and cooperate fully with the SEC," the agency’s acting enforcement director, George Canellos, said in a statement.

CNNMoney (New York) April 22, 2013: 12:26 PM ET

Most stock quote data provided by BATS. Market indices are shown in real time, except for the DJIA, which is delayed by two minutes. All times are ET. Disclaimer. Morningstar: 2015 Morningstar, Inc. Factset: FactSet Research Systems Inc. 2015. Chicago Mercantile Association: Certain market data is the property of Chicago Mercantile Exchange Inc. and its licensors. Dow Jones: The Dow Jones branded indices are proprietary to and are calculated, distributed and marketed by DJI Opco, a subsidiary of S Dow Jones Indices LLC and have been licensed for use to S Opco, LLC and CNN. Standard Poor’s and S are registered trademarks of Standard Poor’s Financial Services LLC and Dow Jones is a registered trademark of Dow Jones Trademark Holdings LLC. All content of the Dow Jones branded indices S Dow Jones Indices LLC 2015 and/or its affiliates.

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Posted by LoHudBlogs.com Admin on Wednesday, November 18th, 2015 at 11:06 pm
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cheap michael kors uk How Timing Belt Replacement Works

November
18

How Timing Belt Replacement Works

The buzzer sounds off; it’s halftime. Your band takes to the field. Before you know it, though, the trumpets play off beat, the cymbals slam into each other and the saxophone player simply walks off the field. This, although exaggerated, is what could happen if the drum major, the keeper of tempo, went missing. And in the world of automotive maintenance, visualizing this scenario can help illustrate the timing belt’s role and what can go wrong without routine replacement.

Think of the synthetic rubber timing belt, which is reinforced with fiber cords, as the drum major of car maintenance meaning it keeps everything in the engine in sync. When the engine is on, it’s in constant, timed motion, thanks to the belt, the connection between the crankshaft and camshaft.

So why is this important? The crankshaft converts linear energy from the pistons, which move up and down, into rotational energy that eventually turns the wheels. The camshaft opens and closes the engine’s valves to allow air and gas in and out of the engine. The timing belt links the two in harmony. Without it, the pistons and valves would collide.

Obviously, this is bad news for vehicle maintenance as this internal collision can cause destruction fair amount of engine damage. Therefore, it’s important to stay ahead of your belt’s lifespan traditionally replacing it every four years or 60,000 miles (96,561 kilometers) or, in newer vehicles, every 100,000 miles (160,934 kilometers). Be sure to check your vehicle’s maintenance manual to see what your car or truck’s manufacturer suggests.

So we’ve all accepted the timing belt’s importance, but that doesn’t mean you have to spend your days worrying that your belt will force you to pay a large maintenance bill. Instead, you can act as the band director and keep that timing belt in check by watching its wear and arming yourself with the knowledge to replace it. Read on to learn about the wear of your belt, typical tools needed in a repair and how to replace it.

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Posted by LoHudBlogs.com Admin on Wednesday, November 18th, 2015 at 11:05 pm
Category: Metropolitan Museum of Art book sale
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cheap michael kors Threat Position in Basketball

November
17

Threat Position in Basketball

Basketball is a great way to break a sweat. Playing basketball allows you to move all your body parts. It can help you lose weight too. There are many positions and techniques in basketball that you can learn in order to master the game. Whether it be amateur or professional basketball, these positions and techniques are very important to ensure a winning game and the improvement of the player. One of the positions crucial to the game is the triple threat position. This position is called such because when you have the ball, you can pass, shoot or dribble the ball. When you are in a triple threat position, you have all the advantage and have the chance to score or let your teammate shoot the ball by passing it to him. If you want to use this position next time you play basketball, this article will show you how. Read on.

Position yourself near the basket. While the ball is still in your teammate’s possession, get as near to the basket as possible so your teammate can pass the ball to you. But do not get too near that you enter the perimeter area and stay there for more than a few second because you will be called for a three second violation.

Ask the ball from your teammate. Let the one holding the ball look at you and signal to him to pass the ball to you. If he sees that you are in a good position, he will immediately give you the possession of the ball.

Do a triple threat position. Once you get the ball, scan the court for the best spot near the basket for this position. You must position yourself in such a way that you see your teammates where you can pass the ball, the basket where you can take a shot and an escape area where you can dribble the ball to get out of the opponent’s defense line.

Decide whether to shoot, dribble or pass. When you are in position, evaluate the situation in the court. If your opponent is in a position where you can do either of the three, determine which move to make. If one of your teammates is nearer to the basket and has more potential to shoot the ball, then you can pass it to him. When there is no one else in the low post for you to pass the ball, you can make the shot, provided your opponent will not get in the way. Lastly, if the opponent is threatening to grab the ball from you, dribble it and get away from your post and find a better spot to make a shot.

When playing basketball, it is important to warm up before the game to prep your muscles and your whole body for the grueling activity ahead and to prevent any sprains and muscle pulls. Use appropriate shoes to avoid having blisters. On the other hand, for you to be a pro in basketball, keep practicing the different moves and techniques during your free time. You will be amazed to discover that these moves and techniques are pretty easy to do. So what are you waiting for? Take out those basketball shoes and jerseys and get to a basketball and bust those moves!

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moncler outlet uk Cyclacel Pharmaceuticals’ CYCC CEO Spiro Rombotis on Q2 2015 Results

November
17

Cyclacel Pharmaceuticals’ CYCC CEO Spiro Rombotis on Q2 2015 Results

Good afternoon and welcome to the Cyclacel Pharmaceutical’s Second Quarter 2015 Earnings Conference Call and Webcast. Today’s call is being recorded. At this time, all participants have been placed in a listen only mode and the floor will be opened for questions following the presentation. [Operator Instructions]

It is now my pleasure to turn the floor over to Bill Harris, Cyclacel’s Corporate Controller. Sir, you may begin.

Thank you, Christine. Good afternoon and welcome to our quarterly conference call. During today’s call, members of our senior management team will review Cyclacel’s financial performance and business highlights for the second quarter ended June 30, 2015.

Before turning the call over to senior management, I would like to remind everyone that during this conference call, any forward looking statements made by management are intended to fall within the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995 and Section 21E of the Securities Exchange Act of 1934, as amended.

As set forth in our press release, forward looking statements involve risks and uncertainties that may affect the company’s business and prospects, including those discussed in our filings with the SEC, which include, among other things, our Form 10 K. These filings are available from the SEC or our website. All of our projections and other forward looking statements represent our judgment as of today and Cyclacel does not take any responsibility to update such information. Judy Chiao, Vice President of Clinical Development and Regulatory Affairs.

At this time, I would like to turn the call over to Spiro Rombotis, our President and CEO.

Thank you, Bill. And good afternoon everyone. Today, I will provide an update on our lead drug candidate sapacitabine together with an update on our progress with our cycling dependent kinase or CDK inhibito programs where we have achieved certain milestones since our last quarterly call.

First let me cover SEAMLESS, our phase 3 file evaluating sapacitabine in the firm line treatment setting of elderly patients with acute myeloid leukemia or AML. Patients eligible for SEAMLESS must be aged 70 years or older and the AML or have refused to receive an induction chemotherapy. The primary end point of the trial is overall survival. The trial was sized for approximately 485 patients and was powered at 90% to detect a 27.5% improvement in overall survival. The experimental arm is a drug regimen of orally dosed sapacitabine and intervenes decitabine and is compared to an active control arm of intervenes decitabine alone. and European sites and we are now in the follow up phase. The product requirement for breaking randomization code is after approximately 424 mortality events. As of this week, approximately 13% of the events remained to be observed. Although, it is difficult to assess when the pre specified in VET number will be met, we estimate this to occur between the second half of 2015 and the first half of 2016.

At that time an independent data management company will break randomization code and conduct initial analysis of the top line results.

We have previously discussed on these calls the outcome of the interim futility and now view that the decision to make submission for regulatory approval will depend on the parity of the data and their clinical relevance in this patient population. We have also previously indicate that decitabine’s prior European approval as a firm line treatment in AML patients, age 65 years or older may have relevance to our assessment of submissibility of the SEAMLESS data.

Recent use in a different AML patient population that is not overlapping with that of SEAMLESS that is patients with relapse of refractory AML may also potentially be relevant.

Let us caution that it is inappropriate to suggest that such examples constitute president, not only are the investigational and control drugs and patient populations different, but so our protocols and the clinical setting suggesting that cross study comparisons could be misleading.

At this point we would like to remind you of our strategy behind SEAMLESS. Elderly patients have limited options after an initial diagnosis of AML. Most of them are unfit or refuse to be treated with nearly 50 year old chemotherapy cocktail of two intravenous drugs. Faced with brick choices and therefore expected survival, they often leg to go to Hospice care.

In recent years, investigators have been suggesting that for elderly AML patients low intensity therapy should be considered. and European hospitals. SEAMLESS offsets AML patients hope of an improved outcome without a hospital admission to receive intensive treatment, which may also expose the compromise immune systems to infections.

If there randomized to the sapacitabine arm of the study, they also benefit by staying in home, well receiving sapacitabine Cyclacel’s by mouth. Quality of life and avoiding exposure to infections are important issues for this patient population. If it reaches the market sapacitabine could become an attractive alternative for elderly patients with AML. While SEAMLESS patients are being followed up, we have continued our planning for potential regulatory submissions.

This includes preparing a pediatric investigational plan for sapacitabine for submission to the European Medicines Agency or EMA. A pediatric investigational plan is required before MAA can be accepted or validated by the EMA. In addition to our focus on SEAMLESS, we have progress our sapacitabine and CDK programs during the quarter and I will summarize some key milestones.

We recently provided updated data from our ongoing Phase 1 trial of an all oral combination of sapacitabine and seliciclib, our first generation CDK2/9 inhibitor in solid tumor patients. Initial data with Cyclacel drug regiment were reported at American Association for Cancer Research 2013 conference by Dr. Geoffrey Shapiro of Dana Farber Cancer Institute and included confirmed and durable partial responses in BRCA positive patients.

In the data update an overall response rate of 55% was observed in heavily pretreated breast, pancreatic patients with BRCA mutations. The durability of responses has been very encouraging with some patients achieving PR and saying on study for more than 90 or 180 weeks. Although data are still maturing we and our clinical investigators have been impressed by the responses and we’ll continue to explore the sapacitabine and CDK inhibitor combination in relevant patient populations.

In addition to our seliciclib CDK program, we also working with our second generation CDK2/9 inhibitor CYC065. CYC065 has much higher potency and a longer patient life than seliciclib and has a potential convenience of both intravenous and/or all dosing. FDA clear our investigation new drug application for IND for CYC065 and we also received Institutional Review Board or IRB approval to begin a first in human Phase 1 study in patients with solid tumors and lymphomas.

The objective of these double escalation study is to evaluate the safety, tolerability and pharmacokinetic profile of CYC065 as a single agent. Assuming this Phase 1 program is successful, the next stage of clinical development will be informed by translation biology and for clinical data which has shown that CYC065 have the potential to be efficacious in cancers that require sustain expression of CDK9 dependent transcripts or activation of CDK2.

This include MCl 1 dependent malignancies, MLL or mixed lineage leukemia rearrangements and [indiscernible] or Cyclin E dependent breast or other gynecological cancers. In terms of its future prospects, CYC065 has been shown to act synergistically with selected DNA damaging or targeted agents.

Seliciclib mechanism of action oral dosing in our clinical database are attractive features for clinical investigators interested in studying the potential of CDK inhibition outside oncology. Last quarter we reported that the patient was dosed in a Phase 2 investigator sponsor trial or IST or Seliciclib in Cushing’s disease and endocrine disorder caused by pituitary tumors. There are limited therapeutic options for Cushing’s disease patients today and Seliciclib could be an important alternative if clinical development is successful.

The primary end point of this IST trial is a number of Cushing disease patients with a normalized 24 hour free cortisal level following four weeks of daily oil dosing of Seliciclib. As this common with ISTs Cyclacel is providing drug clinical supplies, but is not responsible for the study operationally or financially.

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Four longtime Journal News reporters share their insights about fiction, non-fiction, poetry and short stories by bringing books discussions online and exploring the local literati scene. Lots of people say they are booklovers, but Elizabeth Ganga, Barbara Livingston Nackman, Ken Valenti and Randi Weiner really are!


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