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moncler outlet uk Netflix hiking prices by

November
21

Netflix hiking prices by

Existing customers will have grace periods of varying lengths. Pricing for the less popular 1 viewer/no HD and 4 viewer/4K plans isn’t affected.

Netflix also carried out a $1 price hike last year, while promising existing customers won’t see a hike for two years. A hike for European subs was enacted in August.

With Netflix having guided for 69.1M global subscribers at the end of Q3, a $1/month hike for the company’s entire subscriber base would (in theory) generate over $800M in annual revenue. The additional funds could help pay for streaming content obligations that totaled $10.1B at the end of Q2.

Shares have spiked higher after previously trading down as much as 5.1%.

I personally gave up Netflix there wasn’t much for me personally to watch. Each is different and I realized that I was searching more and watching less. These days, I just rent long tail content DVDs from the town library. Or something on HBO Now.

But this is the power of numbers. $12 per year wouldn’t bother anyone who has broadband connection at home and is watching video for entertainment. But for 40m users (assume rest are still $8 or $12 plans), this gives a solid $500 million to Netflix. Wow!

Total opposite here. My wife and I frequently go without cable TV. The only reason I have it now is because it was a package that was something like $10 extra a month above just internet. When our contract is up, I’ll be going back to just internet if there’s not a great deal.

Between Netflix and Amazon Instant Video/Prime, I can watch any show I want and do it cheaper than a cable package! If I can’t find it for free, I just buy the current season and watch them as they come out. Then you own them forever and can re watch them ad free

Although I like the Amazon Prime streaming, I hope people stay away from their pay per view temptations.

To financially support any pay per view system is a decision that ultimately redounds to the disadvantage of consumers. The more money that content owners can make on their content via pay per view outlets, the less likely they will be to license that content to an all you care to watch platform like Netflix and Amazon Prime.

Instead, since most of the current pay per view content is available via Netflix DVD rentals, it makes good sense for consumers to enjoy it that way.

How can that be "optimistic" if it is the number?

The math is this market cap is no longer directly related to fundamentals. That should be clear to a blind person. A stock "certificate" is like a dollar bill. The only time it’s intrinsic value will matter is when there is no desire for investors to own the stock AND there isn’t any intrinsic value. What stock still trades with any relation to the underlying "value" of the company. When does this even matter? When/if the company dissolves is the only time I can think of.

"The only time it’s intrinsic value will matter is when there is no desire for investors to own the stock AND there isn’t any intrinsic value."

Not true just ask the Durch tulip owners back in 1637. As someone who has lived through the previous "dotcom bubble", I can only tell you to be careful. At some point, actual financial returns matter. Maybe not today, maybe not not next week, but at some point. Companies like Cisco and Microsoft had real intrinsic values back then and ever since, yet their equity values are a fraction of what they were back in March of 2001. Enjoy the ride and the great trading in NFLX, it won’t last forever. Reed Hastings himself said that they’re only targeting 5 6M net new subs in this region through 2019 at least. I understand that this eventually trickles down to all US and Canadian subs so I was giving them the benefit of the doubt. No doubt NFLX has some pricing power, however, they also have debt and obligations that are growing much faster than revenues, cash flows, or earnings. Company will be fine. Equity holders will be at risk.

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Posted by LoHudBlogs.com Admin on Saturday, November 21st, 2015 at 9:58 pm |
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longchamp outlet How to Do a forward roll

November
20

How to Do a forward roll

Versatile players with power moves under the basket as well as outside shots. Learn how to play forward and low post in this free basketball lesson video from an experienced coach.

Part 1 of 15 How to Play forward in youth basketball.

The Oklahoma Roll is a great wrestling move that can be used when an opponent has been beating up pretty badly, and he in pain struggling to get up. It very opportunistic but also simple and is used to pin your opponent into submission. You do this by coming off the ropes and doing a forward roll over your opponent. You want your head to stay close to their body so that your head is coming across to the other side of his stomach while you rolling over. While doing this you need to take your right arm and put it over his left shoulder grabbing his left arm. Your left arm is going to.

This is a video tutorial in the Sports category where you are going to learn how to play offense in a game of soccer. The forward soccer position usually stays on the offensive side in order to score goals. Adrian Heath, head coach, shows you how to play the forward position properly. This is going to be a very easy and simple drill. All you are looking for is a nice little floating pass over the defender head to your own player in the forward position. And the forward player then tries to score the goal past the goalkeeper.

In this video, we learn how to adjust your head seat. You want to make sure the top of your stem is adjusted correctly and the spacers are adjusted correctly. Go in and tighten the top cap pole until it just snug. Then, when you grab your bike and roll it forward, go in and tighten it some more. If it too tight, it going to bind up and you won be able to turn your handle bars. Loosen them up as much as you can without them being too loose. From here, you will be able to ride your bike and enjoy!.

Sometimes you will have to pitch underhand whether you are playing softball, baseball or with little kids sometimes a lighter throw is necessary. It may seem odd and unnatural to pitch this way at first, but check out this tutorial for tips on how to toss that ball over the plate with the same force as upperhand pitching.

You Will Need:

A softball

A glove

A softball field

A catcher

A batter (optional)

Step 1: Begin from the set

Hold the ball in the glove at your waist, body relaxed, facing home plate 46 feet away. Touch the rubber slab on the pitcher’s mound with your dominant.

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Posted by LoHudBlogs.com Admin on Friday, November 20th, 2015 at 10:13 pm |
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cheap moncler uk How to Check and change the engine air filter in a car

November
20

How to Check and change the engine air filter in a car

Kim the in house mechanic for Driverside shows you how to quickly and easily replace your cars air filter. The reason you would need to change your air filter is that over time the flow is reduced which consequently reduces your car’s gas mileage. To change your air filter you first need to locate it on your car. The air filter is under the hood and usually in a box that either has clips of fillip’s head screws holding the cover on. Remove these to gain access to your filter. From there you can look to see if you filter is dirty and replace it if necessary. When you’ve finished simply reattach the cover with the screws or clips and you’re good to go.

In this video tutorial, viewers learn how to check and replace the cabin air filter of a car. Most cabin air filters are located behind the glove box of the car. Now go into the car and remove the glove box and put it aside. Some cars may need the glove box to be unscrewed. Now reach in and remove the air filter. If the air filter is dirty, replace it with a new one. Once finished, simply put back in all the parts. This video will benefit those viewers who have a vehicle and would like to learn how to change the air filter to allow clean ventilation through the car.

In this tutorial, we learn how to change the engine and oil filter on a Mercedes car. First, find the oil drain plug underneath the car. Remove this, then let it drain into a pan until it finished leaking out. From here, you will place the drain plug back on, then fill up the vehicle with the correct type of oil from the hood of the car. Then, find where the oil filter is and remove it from the car. Place in the new filter, then tighten all bolts you removed. Check the level in the car to make sure there enough oil, then you are finished!.

In this video, Ed Kriston from AAA Midatlantic explains how to winterize your car. He first talks about the fuel systems. The fuel pump and fuel filter are inside the tank, and lines and hoses run from the tank to the engine. He points out the fuel lines and injectors in the engine, and recommends that you make sure there are no leaks in the lines and hoses. He demonstrates how to remove and examine the air filter and shows one that is dirty that should be replaced. A dirty air filter will compromise engine performance. This video is helpful for anyone interested in learning about.

In this video we learn how to change your engine oil and filter. First, make sure you can go underneath your vehicle. If not place it up on jacks so you can go underneath. After this, find the oil can and then remove the drain plug from it. Let the oil drain into an oil pan until it no longer drains from the car. Next, replace the plug on the bottom of the oil tank and then pop the hood on your vehicle. Remove the cap for the oil tank and then pour your new oil into it. After this, you will replace the cap on the oil tank and then turn the engine one. Check your oil to make sure it filled up.

Watch this video to learn how to do an oil change yourself just using a jack, two jack stands, wrenches, a oil filter wrench, some old rags, oil pan, oil filter, and oil. Just find the oil filter, jack up the car, situate the jack stands, and you ready to start. Once underneath, locate the drain plug, unscrew the bolt, and let it drain. After it drains screw the bolt back on, and find your oil filter. Grab the old filter and twist it off, clean the surrounding area, then replace with the new filter, hand tightening. After getting out from under the car, open the engine compartment, and.

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Posted by LoHudBlogs.com Admin on Friday, November 20th, 2015 at 10:12 pm |
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moncler outlet uk Cyclacel Pharmaceuticals’ CYCC CEO Spiro Rombotis on Q2 2015 Results

November
17

Cyclacel Pharmaceuticals’ CYCC CEO Spiro Rombotis on Q2 2015 Results

Good afternoon and welcome to the Cyclacel Pharmaceutical’s Second Quarter 2015 Earnings Conference Call and Webcast. Today’s call is being recorded. At this time, all participants have been placed in a listen only mode and the floor will be opened for questions following the presentation. [Operator Instructions]

It is now my pleasure to turn the floor over to Bill Harris, Cyclacel’s Corporate Controller. Sir, you may begin.

Thank you, Christine. Good afternoon and welcome to our quarterly conference call. During today’s call, members of our senior management team will review Cyclacel’s financial performance and business highlights for the second quarter ended June 30, 2015.

Before turning the call over to senior management, I would like to remind everyone that during this conference call, any forward looking statements made by management are intended to fall within the Safe Harbor provisions of the Private Securities Litigation Reform Act of 1995 and Section 21E of the Securities Exchange Act of 1934, as amended.

As set forth in our press release, forward looking statements involve risks and uncertainties that may affect the company’s business and prospects, including those discussed in our filings with the SEC, which include, among other things, our Form 10 K. These filings are available from the SEC or our website. All of our projections and other forward looking statements represent our judgment as of today and Cyclacel does not take any responsibility to update such information. Judy Chiao, Vice President of Clinical Development and Regulatory Affairs.

At this time, I would like to turn the call over to Spiro Rombotis, our President and CEO.

Thank you, Bill. And good afternoon everyone. Today, I will provide an update on our lead drug candidate sapacitabine together with an update on our progress with our cycling dependent kinase or CDK inhibito programs where we have achieved certain milestones since our last quarterly call.

First let me cover SEAMLESS, our phase 3 file evaluating sapacitabine in the firm line treatment setting of elderly patients with acute myeloid leukemia or AML. Patients eligible for SEAMLESS must be aged 70 years or older and the AML or have refused to receive an induction chemotherapy. The primary end point of the trial is overall survival. The trial was sized for approximately 485 patients and was powered at 90% to detect a 27.5% improvement in overall survival. The experimental arm is a drug regimen of orally dosed sapacitabine and intervenes decitabine and is compared to an active control arm of intervenes decitabine alone. and European sites and we are now in the follow up phase. The product requirement for breaking randomization code is after approximately 424 mortality events. As of this week, approximately 13% of the events remained to be observed. Although, it is difficult to assess when the pre specified in VET number will be met, we estimate this to occur between the second half of 2015 and the first half of 2016.

At that time an independent data management company will break randomization code and conduct initial analysis of the top line results.

We have previously discussed on these calls the outcome of the interim futility and now view that the decision to make submission for regulatory approval will depend on the parity of the data and their clinical relevance in this patient population. We have also previously indicate that decitabine’s prior European approval as a firm line treatment in AML patients, age 65 years or older may have relevance to our assessment of submissibility of the SEAMLESS data.

Recent use in a different AML patient population that is not overlapping with that of SEAMLESS that is patients with relapse of refractory AML may also potentially be relevant.

Let us caution that it is inappropriate to suggest that such examples constitute president, not only are the investigational and control drugs and patient populations different, but so our protocols and the clinical setting suggesting that cross study comparisons could be misleading.

At this point we would like to remind you of our strategy behind SEAMLESS. Elderly patients have limited options after an initial diagnosis of AML. Most of them are unfit or refuse to be treated with nearly 50 year old chemotherapy cocktail of two intravenous drugs. Faced with brick choices and therefore expected survival, they often leg to go to Hospice care.

In recent years, investigators have been suggesting that for elderly AML patients low intensity therapy should be considered. and European hospitals. SEAMLESS offsets AML patients hope of an improved outcome without a hospital admission to receive intensive treatment, which may also expose the compromise immune systems to infections.

If there randomized to the sapacitabine arm of the study, they also benefit by staying in home, well receiving sapacitabine Cyclacel’s by mouth. Quality of life and avoiding exposure to infections are important issues for this patient population. If it reaches the market sapacitabine could become an attractive alternative for elderly patients with AML. While SEAMLESS patients are being followed up, we have continued our planning for potential regulatory submissions.

This includes preparing a pediatric investigational plan for sapacitabine for submission to the European Medicines Agency or EMA. A pediatric investigational plan is required before MAA can be accepted or validated by the EMA. In addition to our focus on SEAMLESS, we have progress our sapacitabine and CDK programs during the quarter and I will summarize some key milestones.

We recently provided updated data from our ongoing Phase 1 trial of an all oral combination of sapacitabine and seliciclib, our first generation CDK2/9 inhibitor in solid tumor patients. Initial data with Cyclacel drug regiment were reported at American Association for Cancer Research 2013 conference by Dr. Geoffrey Shapiro of Dana Farber Cancer Institute and included confirmed and durable partial responses in BRCA positive patients.

In the data update an overall response rate of 55% was observed in heavily pretreated breast, pancreatic patients with BRCA mutations. The durability of responses has been very encouraging with some patients achieving PR and saying on study for more than 90 or 180 weeks. Although data are still maturing we and our clinical investigators have been impressed by the responses and we’ll continue to explore the sapacitabine and CDK inhibitor combination in relevant patient populations.

In addition to our seliciclib CDK program, we also working with our second generation CDK2/9 inhibitor CYC065. CYC065 has much higher potency and a longer patient life than seliciclib and has a potential convenience of both intravenous and/or all dosing. FDA clear our investigation new drug application for IND for CYC065 and we also received Institutional Review Board or IRB approval to begin a first in human Phase 1 study in patients with solid tumors and lymphomas.

The objective of these double escalation study is to evaluate the safety, tolerability and pharmacokinetic profile of CYC065 as a single agent. Assuming this Phase 1 program is successful, the next stage of clinical development will be informed by translation biology and for clinical data which has shown that CYC065 have the potential to be efficacious in cancers that require sustain expression of CDK9 dependent transcripts or activation of CDK2.

This include MCl 1 dependent malignancies, MLL or mixed lineage leukemia rearrangements and [indiscernible] or Cyclin E dependent breast or other gynecological cancers. In terms of its future prospects, CYC065 has been shown to act synergistically with selected DNA damaging or targeted agents.

Seliciclib mechanism of action oral dosing in our clinical database are attractive features for clinical investigators interested in studying the potential of CDK inhibition outside oncology. Last quarter we reported that the patient was dosed in a Phase 2 investigator sponsor trial or IST or Seliciclib in Cushing’s disease and endocrine disorder caused by pituitary tumors. There are limited therapeutic options for Cushing’s disease patients today and Seliciclib could be an important alternative if clinical development is successful.

The primary end point of this IST trial is a number of Cushing disease patients with a normalized 24 hour free cortisal level following four weeks of daily oil dosing of Seliciclib. As this common with ISTs Cyclacel is providing drug clinical supplies, but is not responsible for the study operationally or financially.

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Posted by LoHudBlogs.com Admin on Tuesday, November 17th, 2015 at 9:52 pm |
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November
13

Hockey heroes return

The Legendary Hockey Heroes are coming back to Kamloops. Players such as Glenn Anderson, Bryan Trottier, Bob Bourne, Larry Melnyk, Ron Flockhart and Warren Skorodenski, along with referee Kerry Fraser, will take on the Media All Stars at Interior Savings Centre on Jan. A portion of the proceeds from each ticket will go to the Royal Inland Hospital Foundation. Tickets are available at 1 800 268 7371 or at the door an hour before game time. The Chase Trojans and Merritt Panthers split a pair of junior basketball games in Chase on Wednesday. The Panthers won the boys’ game 33 18 thanks to Braidon Schonwold’s nine points. Jess Johnson scored 11 for Chase. The Trojans girls got revenge, beating the Panthers 26 23. Nadja Hedrich scored eight points for Chase, with Taylor Carmichael getting eight points for Merritt. Jaida Wallat had 12 points to lead the Sa Hali Sabres junior girls basketball team to a 50 14 victory over the host Valleyview Vikings on Tuesday night. Riley Clark added six points to the winning effort. The South Kamloops Titans, who are ranked No. 5 in provincial senior AAA girls basketball, opened the Okanagan league season with an 84 45 victory over the Salmon Arm Jewels on Tuesday. Emma Wolfram had 32 points and 19 rebounds to lead South Kam, with Ashley Lamoureux scoring 15 points. Maya Olynyk added 13 points. The Titans are off to Edmonton for a weekend tournament. Mairi Sutherland scored 14 points as the South Kamloops Titans ran to a 57 16 victory over the host Ashcroft Rams in a junior girls basketball game Tuesday. Jana Wale also scored 11 points in the victory. Jessica Mazar scored nine points for the Rams. Riley Peterson and Lucas Kemp each scored twice as the Team 8 Ochocincos beat Team 5, 6 5 in a midget recreational hockey game Tuesday. Rylan Spence and Dallas Stachoski also scored for the Ochocinos, who split the goaltending between Michael Clements and Austin Peel. Justin Bartella had three helpers. Nathan Bymoen scored three times for Team 5, which got singles from Mitchell Bymoen and Quinton Ziegelmann and goaltending from Dylan Campbell and Connor Neurater.

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About this blog
Four longtime Journal News reporters share their insights about fiction, non-fiction, poetry and short stories by bringing books discussions online and exploring the local literati scene. Lots of people say they are booklovers, but Elizabeth Ganga, Barbara Livingston Nackman, Ken Valenti and Randi Weiner really are!


What they blog about
Book Notes: An ongoing chat about events, authors and news items about books, libraries, authors and everything literary from metro news reporters Barbara Livingston Nackman and Elizabeth Ganga. Barbara has been a reporter for The Journal News since 1997. She covers municipalities in Putnam County and keeps track of book events everywhere - and began her career writing about books and libraries. Lisa has been a reporter for The Journal News since 2000, after working at several newspapers in Connecticut. She has covered cities and town in sourthern and northern Westchester and is a big Jane Austen fan (though she reads everything from history to mysteries). Both reporters work out of the Mount Kisco bureau and frequently trade tidbits about books and events.


Novel Pursuits: Ken Valenti sheds light on his ongoing experiences as a novelist and poet.  He talks about his trials and tribulations including musings about projects, readings, successes, and even insights into what he is reading and finds interesting. A reporter for The Journal News and its forerunners for more than 20 years, Ken now covers transportation. His first love has been writing fiction, but he's only begun pursuing that dream in recent years. He has been a reader and fiction editor for the journal Inkwell, and has published one short story in another fiction journal.


Seasoned Works: Randi Weiner dishes up an ongoing discussion about all books - old and savory. Though Randi keeps readers abreast of school issues most days and reads lots of children's and young adult books, current science fiction and murder mysteries, her overriding passion is older works generally written before 1940. She chats online about favorites and newly discovered treasures as well as book exhibits and talks related to the dusty, the musty and the marvelous illustrators of the past. She has been a reporter since 1976, with Gannett since 1989. And for the record, she says she has a personal library of more than 4,000 volumes.


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